RESEARCH AND PROOF

A SMALL INSIGHT INTO SOME OF THE RESEARCH AND STUDIES THAT SUPPORT OUR INGREDIENTS

Our ingredients and effectiveness are reviewed and supported by over 35 universities and institutions all over the world.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

INTERNATIONAL SOCIETY OF SPORTS NUTRITION POSITION STAND: CAFFEINE AND PERFORMANCE

Erica R Goldstein, Tim Ziegenfuss, Doug Kalman, Richard Kreider, Bill Campbell, Colin Wilborn, Lem Taylor, Darryn Willoughby, Jeff Stout, B Sue Graves, Robert Wildman, John L Ivy, Marie Spano, Abbie E Smith, and Jose Antonio

​Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA

The Center for Applied Health Sciences, Division of Sports Nutrition and Exercise Science, 3624 West Market Street, STE 104, Fairlawn, OH 44333, USA

MRA Clinical Research, 6280 Sunset Drive #600, Miami, FL 33143, USA

Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA

University of South Florida, School of Physical Education and Exercise Science, Tampa, FL 33620, USA

University of Mary Hardin-Baylor, Belton, TX 76513, USA

Department of Health, Human Performance, and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA

Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA

Department of Human Nutrition, College of Human Ecology, Kansas State University, Manhattan, KS 66506, USA

Department of Kinesiology and Health Education, the University of Texas, Austin, TX 78712, USA

International Society of Sports Nutrition, 600 Pembrook Drive, Woodland Park, CO 80863, USA

Nova Southeastern University, Fort Lauderdale-Davie, FL 33314, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824625/?tool=pmcentrez

 

THE EFFECTS OF SUPPLEMENTATION WITH P-SYNEPHRINE ALONE AND IN COMBINATION WITH CAFFEINE ON RESISTANCE EXERCISE PERFORMANCE

Nicholas A. Ratamess, Jill A. Bush, Jie Kang, William J. Kraemer, Sidney J. Stohs. Vincenzo G. Nocera, Megan D. Leise, Keith B. Diamond and Avery D. Faigenbaum

​Department of Health and Exercise Science, The College of New Jersey

Department of Human Sciences, The Ohio State University

School of Pharmacy and Health Professions, Creighton University

https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0096-5

 

THE PSYCHOPHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL EFFECTS OF SINGLE DOSES OF CAFFEINE IN HEALTHY HUMAN SUBJECTS

M.Bruce, N. Scott, M. Lader & V. Marks

Department of Pharmacology, Institute of Psychiatry, De Crespigny Park ,London SE5 8AF

Pathology Department, Bromley Hospital, Kent

Department of Biochemistry, University of Surrey, Guildford, Surrey

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401080/pdf/brjclinpharm00126-0080.pdf

 

COMPUTATIONAL SYSTEMS ANALYSIS OF DOPAMINE METABOLISM

Zhen Qi, Gary W. Miller, and Eberhard O. Voit

​Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Medical School, Atlanta, Georgia, United States of America

Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, United States of America,

Chiba University Center for Forensic Mental Health, Japan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824625/?tool=pmcentrez

 

EMOTIONAL ENHANCEMENT OF MEMORY: HOW NOREPINEPHRINE ENABLES SYNAPTIC PLASTICITY

Keith Tully and Vadim Y Bolshakov

​Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877027/

 

NEW MELANIC PIGMENTS IN THE HUMAN BRAIN THAT ACCUMULATE IN AGING AND BLOCK ENVIRONMENTAL TOXIC METALS

Luigi Zecca, Chiara Bellei, Patrizia Costi, Alberto Albertini, Enrico Monzani, Luigi Casella, Mario Gallorini, Luigi Bergamaschi, Alberto Moscatelli, Nicholas J. Turro, Melvin Eisner, Pier Raimondo Crippa, Shosuke Ito, Kazumasa Wakamatsu, William D. Bush, Weslyn C. Ward, John D. Simon, and Fabio A. Zuccaa

​Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Milan, Italy;

Department of General Chemistry, University of Pavia, 27100 Pavia, Italy;

National Institute of Metrology, Unit of Radiochemistry and Spectroscopy, 27100 Pavia, Italy;

Department of Chemistry, Columbia University, New York, NY 10027;

Department of Physics, University of Houston, Houston, TX 77204-5506;

Department of Environmental Sciences, University of Parma, 43100 Parma, Italy;

Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan; and

Department of Chemistry, Duke University, Durham, NC 27708

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582310/

 

RELEVANCE OF NOREPINEPHRINE–DOPAMINE INTERACTIONS IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER

 Mostafa El Mansari, Bruno P Guiard, Olga Chernoloz, Ramez Ghanbari, Noam Katz, and Pierre Blier

​University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4

Correspondence: Mostafa El Mansari, Ph.D., University of Ottawa Institute of Mental Health Research, Room 7407, 1145 Carling Avenue, Ottawa ON K1Z 7K4, Canada

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904493/

 

EFFECT OF CYTIDINE DIPHOSPHATE CHOLINE (CDP-CHOLINE) ON ISCHEMIA-INDUCED ALTERATIONS OF BRAIN LIPID

Gianfranco Trovarelli, Gianna Evelina De Medio, Robert V. Dorman, Gian Luigi Piccinin, Lloyd A. Horrocks, Giuseppe Porcellati

Istituto di Chimica BiologicaUniversità di PerugiaPerugia Italy

Department of Physiological ChemistryThe Ohio State University Columbus

.Clinica NeurologicaUniversità di PerugiaPerugia Italy

https://link.springer.com/article/10.1007%2FBF00965041#citeas

 

L-THEANINE EXTENDS LIFESPAN OF ADULT CAENORHABDITIS ELEGANS

Kim Zarse, Saskia Jabin, and Michael Ristow

​Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419347/

 

PHARMACOLOGY AND THERAPEUTIC USES OF THEANINE

Eschenauer G, Sweet BV.

​College of Pharmacy, University of Michigan Health System, Ann Arbor, MI 48109-0008, USA.

http://www.ajhp.org/content/63/1/26?sso-checked=true

 

IMPROVING MENTAL REGENERATION AFTER PHYSICAL EXERCISE

Ralf Jäger, Martin Purpura, Kurt-Reiner Geiss, Thorsten Barthel, Reinhard Schnittker, and Michael Weiß

​Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI 53202, USA

ISME, Weingartenstr. 2, 64546 Mörfelden-Walldorf, Germany

Department of Sport and Health, University of Paderborn, Warburger Str. 100, 33098 Paderborn, Germany

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313114/

 

HERBAL EXTRACTS AND PHYTOCHEMICALS: PLANT SECONDARY METABOLITES AND THE ENHANCEMENT OF HUMAN BRAIN FUNCTION

David O. Kennedy and Emma L. Wightman

​Brain, Performance and Nutrition Research Centre, School of Life Sciences, Northumbria University, Newcastle, NE1 8ST UK

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042794/

 

SCHIZANDROL A: A LIGNAN FROM SCHISANDRA CHINENSIS

Liang Zhao, Xiaoling Yu, and Chungang Chena

​School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, People’s Republic of China

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962140/

 

THERMOGENIC EFFECT OF AN ACUTE INGESTION OF A WEIGHT LOSS SUPPLEMENT

Jay R Hoffman, Jie Kang, Nicholas A Ratamess, Stefanie L Rashti, Christopher P Tranchina, and Avery D Faigenbaum

​Department of Health and Exercise Science, The College of New Jersey, PO Box 7718, Ewing, New Jersey 08628, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621121/

 

PREDICTORS OF WEIGHT LOSS AND MAINTENANCE IN PATIENTS TREATED WITH ANTIOBESITY DRUGS

Federica Guaraldi, Uberto Pagotto, and Renato Pasquali

​Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;

Division of Endocrinology, Department of Clinical Medicine, S Orsola-Malpighi Hospital, Alma Mater Studiorum University, Bologna, Italy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139531/

 

IDENTIFICATION OF HIGENAMINE IN RADIX ACONITI LATERALIS PREPARATA AS A BETA2-ADRENERGIC RECEPTOR AGONIST1

Bai G, Yang Y, Shi Q, Liu Z, Zhang Q, Zhu YY.

​College of Life Sciences, Nankai University, Tianjin 300071, China

https://www.ncbi.nlm.nih.gov/pubmed/18817623

 

THE RELAXATION EFFECT AND MECHANISM OF ACTION OF HIGENAMINE IN THE RAT CORPUS CAVERNOSUM

Kam SC, Do JM, Choi JH, Jeon BT, Roh GS, Chang KC, Hyun JS.

​Department of Urology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.

https://www.ncbi.nlm.nih.gov/pubmed/21956762

 

BETA2-ADRENOCEPTOR-MEDIATED TRACHEAL RELAXATION INDUCED BY HIGENAMINE FROM NANDINA DOMESTICA THUNBERG

Tsukiyama M, Ueki T, Yasuda Y, Kikuchi H, Akaishi T, Okumura H, Abe K.

​Faculty of Pharmacy, Musashino University, Tokyo, Japan.

https://www.ncbi.nlm.nih.gov/pubmed/19468973

 

EFFECTS OF HIGENAMINE ON THE CARDIO-CIRCULATORY SYSTEM

Zhou SJ, Du GY.

Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China

https://www.ncbi.nlm.nih.gov/pubmed/15620176

 

A REVIEW OF THE RECEPTOR-BINDING PROPERTIES OF P-SYNEPHRINE AS RELATED TO ITS PHARMACOLOGICAL EFFECTS

Sidney J. Stohs, Harry G. Preuss, and Mohd Shara

​School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA

Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039, USA

Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166186/

 

EFFECTS OF P-SYNEPHRINE ALONE AND IN COMBINATION WITH SELECTED BIOFLAVONOIDS ON RESTING METABOLISM, BLOOD PRESSURE, HEART RATE AND SELF-REPORTED MOOD CHANGES

Sidney J. Stohs, Harry G Preuss, Samuel C. Keith, Patti L. Keith, Howard Miller, and Gilbert R. Kaats

​Dean Emeritus, Creighton University Health Sciences Center, Omaha, NE 68178, USA

Department of Physiology, Georgetown University Medical Center, Washington, DC, USA

Integrative Health Technologies, Inc., 4940 Broadway, San Antonio, TX 78209, USA

Nutratech Inc., West Caldwell, NJ 07006, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085176/

 

NOOPEPT STIMULATES THE EXPRESSION OF NGF AND BDNF IN RAT HIPPOCAMPUS

Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB.

​V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.

https://www.ncbi.nlm.nih.gov/pubmed/19240853

 

PHARMACOKINETICS OF NEW NOOTROPIC ACYLPROLYLDIPEPTIDE AND ITS PENETRATION ACROSS THE BLOOD-BRAIN BARRIER AFTER ORAL ADMINISTRATION

Boiko SS, Ostrovskaya RU, Zherdev VP, Korotkov SA, Gudasheva TA, Voronina TA, Seredenin SB.

​Laboratory of Pharmacokinetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.

https://www.ncbi.nlm.nih.gov/pubmed/10977920

 

 

EFFECT OF ORAL CDP-CHOLINE ON PLASMA CHOLINE AND URIDINE LEVELS IN HUMANS

Richard J. Wurtman, Meredith Regan, Ismail Ulus and Lilly Yu

​Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, U.S.A.

http://web.mit.edu/dick/www/pdf/972.pdf

 

EFFECTS OF CDP-CHOLINE ON NEUROLOGIC DEFICITS AND CEREBRAL GLUCOSE METABOLISM IN A RAT MODEL OF CEREBRAL ISCHEMIA

Mitsuru Kakihana, MS, Naohisa Fukuda, PhD, Masahiro Suno, PhD, and Akinobu Nagaoka, PhD

​Biology Laboratories, Central Research Division, Takeda Chemical Industries, Limited, Osaka, Japan.

https://www.ahajournals.org/doi/pdf/10.1161/01.str.19.2.217

 

EFFECTS OF CDP-CHOLINE ON COGNITION AND CEREBRAL HEMODYNAMICS IN PATIENTS WITH ALZHEIMER'S DISEASE

Caamaño J, Gómez MJ, Franco A, Cacabelos R.

​Institute for C.N.S. Disorders, Basic & Clinical Neurosciences Research Center, La Coruña, Spain.

https://www.ncbi.nlm.nih.gov/pubmed/7913981

 

RETROSPECTIVE AND OBSERVATIONAL STUDY TO ASSESS THE EFFICACY OF CITICOLINE IN ELDERLY PATIENTS SUFFERING FROM STUPOR RELATED TO COMPLEX GERIATRIC SYNDROME

Salvatore Putignano, Pietro Gareri, Alberto Castagna, Giuliano Cerqua, Pasquale Cervera, Antonino Maria Cotroneo, Francesco Fiorillo, Roberto Grella, Roberto Lacava, Antonio Maddonni, Saverio Marino, Alice Pluderi, Daria Putignano, and Filomena Rocca

​Associazione Geriatri Extraospedalieri – Geriatria Italiana Territoriale, Tenore 17, Naples, Italy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363302/?tool=pubmed

 

COMPUTATIONAL SYSTEMS ANALYSIS OF DOPAMINE METABOLISM

Zhen Qi, Gary W. Miller, and Eberhard O. Voit

​Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Medical School, Atlanta, Georgia, United States of America

Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, United States of America

Chiba University Center for Forensic Mental Health, Japan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435046/

 

PLASMA DOPA LEVELS AND GROWTH HORMONE RESPONSE TO LEVODOPA IN PARKINSONISM

A Galea-Debono, P Jenner, C D Marsden, J D Parkes, D Tarsy, and J Walters

​University Department of Neurology, Institute of Psychiatry, and King's College Hospital, London

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC492632/

 

EMOTIONAL ENHANCEMENT OF MEMORY: HOW NOREPINEPHRINE ENABLES SYNAPTIC PLASTICITY

Keith Tully and Vadim Y Bolshakov

Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877027/